Newsletter | April 6, 2021

04.06.21 -- How To Say Goodbye To Residual DNA

 
Optimization Strategy And Process Economics Of DNA Digestion In Viral Vector Production For Gene Therapy
 

Benzonase® endonuclease is a high-quality product delivering immense value to viral vector processes. The enzyme activity is strongly influenced by the matrix and optimization of its use should be a mandatory step in process development. This article highlights an optimization strategy and the process economics of DNA digestion in viral vector purification.

Strategies For Clarifying Harvest Feed Streams In Viral Vector Bioprocessing
 

Depth filtration and Benzonase® endonuclease digestion are considered gold-standard unit operations in adeno associated virus (AAV) production processes. Optimization of this midstream set of unit operations use should be considered a mandatory and often crucial step in process development. This poster explores data-driven strategies for clarifying harvest feed streams.

Risk Mitigation Strategies For Raw And Starting Materials Used In Gene Therapies
 

Manufacturers are faced with many challenges in the journey from development to commercialization. Within this challenging environment, a number of risk mitigation strategies related to the materials used to produce viral vectors can be employed to help accelerate progress toward commercialization of these remarkable therapeutics.

Downstream Process Intensification For Virus Purification
 
With the rise of gene therapy as a promising treatment modality, the industry is facing increasing pressure to decrease overall manufacturing costs, shorten product development timelines, and increase production. This webinar focuses on intensified downstream processes using high-productivity, single-use chromatography membrane adsorbers.
Solutions
Benzonase® endonuclease Safety Plus Emprove® Expert

Benzonase® endonuclease is the smart solution for DNA removal in biopharmaceutical production. The stringent quality control and extensive documentation packages that are part of Benzonase® endonuclease Emprove® Expert, the new Safety Plus product, enhance quality levels even further by adding the most recent manufacturing and analytical technologies delivering elevated risk mitigation.

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