Considerations For Media And Mixing: Developmental, Clinical, And Commercial Phases

By Ahmed Abouzeid and David Menahem, Sartorius

There are a number of key considerations drug developers must evaluate in the early phases of preclinical and clinical work. While each is important to delivering an optimal final product, some organizations may neglect to adequately prioritize certain elements in favor of agility or short-term cost savings. Media and mixing are two such considerations – while many developers are keen to optimize media and mixing for a given application, they may lack the incumbent expertise and experience necessary to evaluate all of the key variables that influence media preparation and scaling.

Regardless of phase, media and mixing optimization can afford operators an advantage in speed and efficiency for drug processing; likewise, failing to prioritize media preparation can serve to compromise it. Ultimately, there are three core factors that influence media preparation that organizations must consider in order to optimize media at each stage:

• Media and mixing performance
• Analytics and data
• Process optimization

By prioritizing these factors at the developmental, clinical, and commercial phases, organizations can establish a robust, reproducible media preparation process that incorporates advanced analytics and supplier expertise to ensure consistency and quality. In doing so, they can establish process control and monitoring that minimizes or eliminates suboptimal or compromised media batches.