Newsletter | August 22, 2025

08.22.25 -- Developing An In Vivo CAR-T

FEATURED PODCAST

Developing An In Vivo CAR-T With Interius BioTherapeutics' Sianny Christanti And Babu Medi, Ph.D.

 On this episode of Better Biopharma, Interius BioTherapeutics’ Sianny Christanti and Babu Medi, Ph.D., explain how the company is re-engineering a lentiviral vector to enable INT2104, its off-the-shelf, in vivo CAR T-cell therapy. They discuss the vector's design and its manufacturability, as well as the analytical and regulatory challenges of bringing this first-in-human therapy to the clinic.

INDUSTRY INSIGHTS

The New Language Of E6 R3: What Makes The Guidelines So Different?

Unpack the significant changes in ICH E6 (R3), nearly a decade after its last update. This revision brings renewed focus to quality by design and digital provenance.

Optimizing Bioprocesses Using Functional DOE

Combining Functional Design of Experiments (Functional DOE) with traditional DOE methods enhances biopharmaceutical process optimization by capturing dynamic, time-based variations in cell culture systems.

My Life Changed Forever: A Breast Cancer Journey Of Hope And Advocacy

This "In Their Shoes" video shares LaToya Bolds-Johnson's journey with breast cancer and her advice to others going through similar struggles.

When Science And Humanity Become Inseparable

Scientific breakthroughs mean nothing if families can’t reach them. Learn how kindness transformed the clinical trial experience for pediatric rare disease participants in a global study.

Why Human Insight Remains Essential In The Age Of AI

In an age defined by the allure of AI-driven automation and big-data analytics, technological adoption is often mistaken for innovation. Yet true competitive advantage hinges on the human capacity to think critically.

Critical Steps To Optimize Viral Vector Manufacturing With CDMOs

To develop a fruitful viral vector manufacturing process and a mutually beneficial relationship between sponsor and CDMO, learn to balance cost, quality, and timeline via transparent communication.

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