LNP Formulation For mRNA Delivery

In this series, Cytiva scientists share their journey and insights on mRNA synthesis for research purposes and they share their advice on how to scale.

Microfluidic mixing is one of the most effective means to formulate lipid nanoparticles (LNPs) because of its scalability and reproducibility. An aqueous buffer containing mRNAs and an organic lipid mixture are rapidly mixed in a controlled and non-turbulent manner, facilitating self-assembly into stable nanostructures.

Explore LNP formulation, LNP polishing, sterile filtration of mRNA-LNPs, and more.