Article | December 2, 2013

Maximizing Pipeline Value and Operational Efficiency through High Throughput Protein Expression

Source: Life Science Leader

At the core of every drug development program is the challenge to successfully express active, high quality product, and this is especially true of biologics. Indeed, very frequently drug developers are faced with protein expression issues, struggling to express a specific protein for months (and sometimes years) with varying degrees of success; low or no expression, insoluble expression, proteolytic clipping of the expressed protein or a combination thereof are examples of the hurdles encountered in product development efforts. Such challenges in protein expression are a major source of biopharmaceutical development delays, particularly as production strain development is typically performed in a linear and iterative fashion.