PBPK Modelling For Optimizing Controlled Release Dosage Form Development

When developing controlled release dosage forms, it can be a challenge to create a formulation to release the drug at a modulated rate or at a specific site in the gastrointestinal tract. Physiologically-based pharmacokinetic (PBPK) modeling is a tool that can help streamline controlled release dosage form development. By taking into consideration active pharmaceutical ingredient (API) physicochemical properties and available pharmacokinetic (PK) data, it is possible to predict the dissolution profiles that are most likely to meet the desired in vivo PK profiles, and guide formulation development.

Examine the benefits of controlled release, the application of PBPK modeling in controlled release formulation development, and how modified release products can be developed to deliver optimal patient outcomes.