Biocatalysis: Solving Scale-Up Issues with Biocatalysed Reactions

June 17 - 18, 2024 - GB

Scientific Update Ltd

This is online short course will look at biocatalysed/biotransformation reactions to make pharma/agrochem chem intermediates, API’s and fine chemicals. the focus is on scale-up issues and getting productive process established. June 17th, 1.30 – 4.30 pm (UK) | Session 1 June 18th, 1.30 – 4.30 pm (UK) | Session 2 Many forays by organic chemists into using biocatalysis in chemical synthesis stall at the initial scale-up stage. Screening and small scale (gram) reactions progress as planned, but when scaled -up, reactions stall, take more enzyme than expected, work-ups end up with emulsion issues etc. This course will look at some of the techniques and technologies ( tricks of the trade) that can help derisk scaling up biocatalysed reactions .A further barrier to the adoption of more biocatalytic reactions are production / EHS scientists who are unsure how to handle enzymes in the plant/pilot plant. the course will also look at good sources of information/data to facilitate the use of enzymes at scale. Enzyme supply chain: Storage, stability etc Techno-economic analysis – will the transformation ever hit the required targets? Different types of strains used and its safety impactions. Using GMO’s and GMO derived materials Handling concerns related to enzyme -SHE/EHS issues., Safety issues in scaling up biocatalytic reactions Pros and cons of different enzyme formulations Enzyme stability: General to pH, co-solvent, temperature as linked to process design and development Enzyme analysis / characterisation – needed to assess purity in order to calculate activity and so expected long term cost, spec setting / quality control (ensure plant samples match lab samples and measure variation over time). Scale-up – reactor options – various reactor types, std batch, continuous, membrane separated, continuous liquid extraction, etc Product isolation from complex mix . Enzyme removal/ downstream processing– to be intelligent in terms of what can and can’t be removed vs effects on process including downstream chemistry. Use of immobilised enzymes/ Recycling of immobilised enzymes Some IP considerations Time: 1:30 PM - 4:30 PM

More Information