Cytiva product datasheets, catalogs, app notes

1. Optimizing TFF And SPTFF For High-Concentration mAb Formulations 4/9/2025

   Discover the critical role of formulation buffer composition in stabilizing monoclonal antibodies during tangential flow filtration, a process involving ultrafiltration and diafiltration under high pressure and shear forces.

2. Production Of A Highly Concentrated Monoclonal Antibody 10/4/2024

   The production of a highly concentrated monoclonal antibody requires many process steps. Discover how to achieve a final mAb concentration above 200 g/L while maintaining critical quality attributes.

3. Extractables In Single-Use Systems Used In ADC Manufacturing 9/23/2024

   To address concerns about using organic solvents in the ADC process, extractables studies were conducted on a disposable chromatography column housing and two different disposable flow paths.

4. Adapting Single-Use Chromatography To Manufacturing Scale 5/16/2024

   Explore strategies for accommodating the ever-increasing upstream titers and volumes to prevent downstream purification from becoming a bottleneck.

5. Developing A Large-Scale Tangential Flow Filtration Process 5/13/2024

   Discover a process that can be modified to fit your downstream process and serves as a complete solution for concentration and diafiltration.

6. Bulk Filling Of Drug Substance | Accurate Aliquoting 4/24/2024

   Bulk filling drug substances in traditional facilities is often a lengthy, manual process where operators are relied upon to adjust pump controls to achieve accurate filling. This method, spanning multiple shifts, increases process risk through errors that can compromise accuracy.

7. Sterilizing Grade Filter Performance With Biologic Drugs 3/11/2024

   Examine the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins as well as how filter selection can impact your process.

8. Developing A HIC Polishing Step For The Removal Of mAb Aggregates 9/28/2023

   Learn in-depth about the development of a flow-through polishing step that employs hydrophobic interaction chromatography for the elimination of monoclonal antibody aggregates.

9. Alkaline Stability Of Modern Protein A Chromatography Resins 7/12/2023

   Explore results from a resin lifetime study with over 150 cycles, using clarified cell harvest in every cycle, which has been performed to evaluate the alkaline stability of three protein A resins.

10. Protein L Affinity Resin Is Ready To Move To Manufacturing 7/12/2023

    Discover a protein L affinity chromatography resin that is well suited for use in biomanufacturing and offers increased binding capacities compared to other resins.