By Wayne Koberstein, Executive Editor, Life Science Leader magazine
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Challenging drug resistance with a retooled antibiotic and a broad mechanism of action.
Zavante has completed a pivotal Phase 2/3 trial of its lead broad-spectrum antibiotic drug, ZOLYD (fosfomycin injection), for treating complicated urinary tract infections (cUTI) and expects to fi le a new drug application for the product in mid-2018. Fosfomycin has a long history outside the U.S., but the company has recast the injectable to improve its pharmacokinetics and pharmacodynamics against acute infections in a hospital setting. ZOLYD has a unique mechanism of action and is targeted at GRAM-positive and GRAM-negative infections, including those caused by multidrug-resistant bacteria.