Discovery/R&D

1. Gene Tx For Renal Disease With Purespring CEO Richard Francis 5/2/2022

   Purespring Therapeutics launched in 2020 on the back of IP developed by renowned kidney researcher Prof. Moin Saleem, who spent decades working on podocytes when podocytes weren’t cool. Just two years later, the company boasts three gene therapy assets and a platform developed expressly to identify new therapeutic targets to address kidney disease. 

2. Turning The Liver Into A mAb Factory With Homology's Arthur Tzianabos, Ph.D. 11/15/2021

   Homology Medicines' approaches to gene therapy and gene editing have the potential to seriously disrupt both the cell/gene therapy space \_and\_ the mAb manufacturing and administration paradigms as we know them. On this episode of the Business of Biotech, Homology President & CEO Arthur Tzianabos, Ph.D. shares the company's approach and supports its rationale for investing in its own development and manufacturing capacity.

3. Accelerating ADCs with Mythic Therapeutics' Brian Fiske, Ph.D. 5/26/2024

   Mythic Therapeutics Chief Scientific Officer and Co-Founder Brian Fiske, Ph.D. broke some unwritten protocol with his rapid and multifaceted transition from academia to industry. He calls his many, and sometimes concurrent, early experiences as an MIT Ph.D. student, a Flagship Ventures Fellow, a Bain consultant, a hospital researcher, and a biopharma consultant indicative of a young man who didn't want to make decisions.

4. Functional Ectopic Organs with LyGenesis' Michael Hufford, Ph.D. 4/5/2023

   What sounds like science fiction to some is starting to look like a life changing therapy for millions of liver, kidney, pancreas, and thymus disease sufferers, LyGenesis is developing a pipeline of allogeneic cell therapies using the lymph node as an in vivo bioreactor to grow functioning ectopic organs. The science behind it is being developed not in Boston, not in Philadelphia, nor in San Franciso, but right in the heart of the rust belt in Pittsburgh, PA. This week's episode of the Business of Biotech takes us there for a conversation with LyGenesis CEO Dr. Michael Hufford, Ph.D.

5. Building An Efficient Biopharma With South Rampart Pharma's Hernan Bazan, M.D. 7/16/2025

   On this week's Business of Biotech, Dr. Hernan Bazan, M.D., co-founder and CEO at New Orleans-based South Rampart Pharma, talks about building an ultra-lean drug development company to address an unmet need observed in his own patients as a surgeon: safe treatments for acute pain.

6. Innovating On The Frontier Of Radiopharmaceuticals With RadioMedix's Ebrahim Delpassand, M.D. 7/23/2025

   On this week's Business of Biotech episode, Ebrahim Delpassand, M.D., founder, CEO, and chairman of the board at RadioMedix talks about his personal journey standing up and growing a radiopharmaceutical company focused on oncology.

7. BoB@JPM: Support Of A Blossoming Pipeline With Sangamo's Sandy Macrae, Ph.D. 2/5/2023

   The Business of Biotech podcast took to the streets of San Francisco during the 41st Annual J.P. Morgan Healthcare Conference. This week's episode features a conversation with Sangamo Therapeutics CEO Sandy Macrae, Ph.D., who rationalizes the company's aggressive pipeline development and its decision to invest in multinational AAV and cell therapy manufacturing facilities in France and California. Dr. Macrae zeroes in on the relationship between people and processes that's enabled the company to grow to more than 500 associates working on nearly 20 cell therapy, gene therapy, and genome engineering programs. 

8. Modernizing Clinical Trial Operations With Merck's Jennifer Sheller 12/18/2025

   On this episode of the Business of Biotech, Jennifer Sheller, SVP and Head of Global Clinical Trial Operations at Merck talks about simplifying trial protocols and what she likes about Merck's hybrid functional service provider model for conducting trials in over 60 countries. 

9. Intranasal Prophylactics For Flu & Coronavirus With Leyden Labs' Koenraad Wiedhaup 8/2/2021

   As Leyden Labs Founder & CEO Koenraad Wiedhaup puts it, we breathe in galaxies of viruses on a daily basis. As those viruses multiply and mutate, our approach to mitigating their risks is largely reactive. That's why his new company is busy developing a prophylactic approach to protecting populations from a host of influenza and coronaviruses via a self-administered intranasal spray. Learn how the company came to be, how its development efforts were buoyed by a recent $40 million series A investment, and why Wiedhaup believes intranasal prophylactics are ready to play a role in prevention of the next pandemic on this episode of the Business of Biotech podcast.

10. BoB@JPM: Academia To Industry With Oncolytics' Matt Coffey, Ph.D. 2/12/2023

    The JP Morgan Healthcare Conference is a target-rich environment for conversations with the leaders of up-and-coming biopharma companies, so we took the Business of Biotech on the road. On today's episode, we sat down with Matt Coffey, Ph.D., who earned his Ph.D. in 1998 and turned his doctoral thesis into a biopharma company called Oncolytics in 1999. Dr. Coffey shares on his abrupt transition from academia to industry, tells tales of the company's backstory, and updates us on its aggressive clinical activity spanning 7 wide-ranging oncology programs.